Friday, April 16, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:45pm | Softball - Armstrong vs Penn Hills # | |
| 5:00pm | Baseball - Norwin vs Mt. Lebanon # | |
| 5:00pm | Baseball - Canon-McMillan @ Pine-Richland | |
| 5:00pm | Baseball - Latrobe vs Fox Chapel | |
| 5:00pm | Baseball - Hempfield @ Bethel Park | |
| 5:00pm | Baseball - Penn-Trafford @ Penn Hills | |
| 5:00pm | Baseball - Shaler vs Peters Township | |
| 5:00pm | Softball - Hempfield @ Seneca Valley # | |
| 5:00pm | Softball - Norwin vs Pine-Richland # | |
| 5:00pm | Softball - Indiana @ Kiski Area # | |
| 5:00pm | Softball - Latrobe @ Connellsville # | |
| 5:00pm | Softball - Franklin Regional vs Gateway # | |
| 5:15pm | Baseball - Moon vs Quaker Valley | |
| 6:15pm | Softball - Bethel Park @ Canon-McMillan # | |
| 6:30pm | Softball - Penn-Trafford vs Thomas Jefferson # |
# denotes a conference game