Friday, April 23, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Softball - Mars @ Moon | |
| 4:45pm | Baseball - Armstrong vs Highlands | |
| 4:45pm | Softball - Hampton vs Fox Chapel # | |
| 5:00pm | Baseball - Kiski Area @ McKeesport # | |
| 5:00pm | Baseball - South Fayette vs Central Catholic | |
| 5:00pm | Baseball - Connellsville @ Greensburg Salem | |
| 5:00pm | Baseball - Franklin Regional vs Leechburg | |
| 5:00pm | Baseball - Penn Hills vs St. Joseph | |
| 5:00pm | Baseball - Trinity @ Ringgold | |
| 5:00pm | Softball - Hempfield vs Norwin # | |
| 5:00pm | Softball - Plum @ Kiski Area # | |
| 5:00pm | Softball - Thomas Jefferson vs Albert Gallatin # | |
| 5:00pm | Softball - West Allegheny vs Upper St. Clair # | |
| 5:00pm | Softball - Armstrong @ Highlands | |
| 5:00pm | Softball - Seneca Valley vs Elizabeth Forward | |
| 5:00pm | Softball - Franklin Regional @ West Mifflin | |
| 5:00pm | Softball - Penn Hills vs Gateway | |
| 5:00pm | Softball - Western Beaver @ South Side Beaver | |
| 5:15pm | Baseball - Norwin vs North Allegheny | |
| 5:15pm | Baseball - Hempfield vs Plum | |
| 5:15pm | Softball - Canon-McMillan vs Pine-Richland | |
| 5:15pm | Softball - South Fayette @ Chartiers-Houston | |
| 5:30pm | Baseball - West Allegheny vs Latrobe | |
| 5:30pm | Softball - Penn-Trafford @ North Hills | |
| 6:00pm | Baseball - Fox Chapel @ Woodland Hills # | |
| 7:00pm | Boys Basketball - Upper St. Clair vs Reading | |
| 8:00pm | Softball - North Allegheny vs Butler # | |
| 8:30pm | Baseball - Butler vs Grove City |
# denotes a conference game