Friday, August 27, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Baldwin @ McKeesport | |
| 8:00pm | Football - Canon-McMillan @ Trinity | |
| 8:00pm | Football - Hempfield vs Greensburg Salem | |
| 8:00pm | Football - Mt. Lebanon @ Bethel Park | |
| 8:00pm | Football - Norwin @ Penn-Trafford | |
| 8:00pm | Football - Peters Township vs Fox Chapel | |
| 8:00pm | Football - South Fayette @ Montour | |
| 8:00pm | Football - Upper St. Clair vs Greensburg Central Catholic | |
| 8:00pm | Football - Connellsville vs Laurel Highlands | |
| 8:00pm | Football - Franklin Regional vs Plum | |
| 8:00pm | Football - Gateway vs Delaware Valley | |
| 8:00pm | Football - Latrobe vs Derry Area | |
| 8:00pm | Football - Kiski Area vs Butler | |
| 8:00pm | Football - North Hills @ Mars | |
| 8:00pm | Football - Shaler @ New Castle | |
| 8:30pm | Football - North Allegheny vs Allderdice | |
| 8:30pm | Football - Seneca Valley vs Moon | |
| 10:00pm | Football - Central Catholic vs Imhotep Charter |
# denotes a conference game