Friday, September 10, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 7:00pm | Football - Central Catholic @ Pine-Richland | |
| 7:00pm | Football - Gateway @ Penn Hills | |
| 7:30pm | Boys Soccer - Shaler vs Allderdice | |
| 8:00pm | Football - Baldwin @ Upper St. Clair | |
| 8:00pm | Football - Canon-McMillan @ Bethel Park | |
| 8:00pm | Football - Hempfield vs Franklin Regional | |
| 8:00pm | Football - Mt. Lebanon @ Peters Township | |
| 8:00pm | Football - North Allegheny vs Mentor (OH) | |
| 8:00pm | Football - Norwin @ Connellsville | |
| 8:00pm | Football - Seneca Valley @ North Hills | |
| 8:00pm | Football - Moon @ Woodland Hills | |
| 8:00pm | Football - South Fayette @ Thomas Jefferson | |
| 8:00pm | Football - West Allegheny @ Montour | |
| 8:00pm | Football - Penn-Trafford @ Belle Vernon | |
| 8:00pm | Football - Fox Chapel @ Plum | |
| 8:00pm | Football - Shaler @ Hampton | |
| 9:00pm | Football - Latrobe vs Kiski Area |
# denotes a conference game