Wednesday, October 20, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 7:15pm | Girls Volleyball - Bethel Park @ Moon # | |
| 7:30pm | Boys Soccer - Mt. Lebanon @ South Fayette | |
| 7:30pm | Boys Soccer - Connellsville vs Mt. Pleasant | |
| 7:30pm | Girls Soccer - Seneca Valley vs West Allegheny | |
| 7:30pm | Girls Soccer - Baldwin @ Montour | |
| 7:30pm | Girls Soccer - Latrobe @ Franklin Regional | |
| 7:30pm | Girls Volleyball - North Hills @ Upper St. Clair |
# denotes a conference game