Friday, November 5, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Bethel Park vs Woodland Hills | |
| 8:00pm | Football - Penn Hills vs Franklin Regional | |
| 8:00pm | Football - Upper St. Clair vs Fox Chapel | |
| 8:00pm | Football - North Hills vs Peters Township | |
| 8:00pm | Football - North Allegheny vs Canon-McMillan |
# denotes a conference game