Friday, February 25, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 7:00pm | Boys Basketball - North Hills vs North Allegheny | |
| 7:00pm | Boys Basketball - Fox Chapel vs Pine-Richland | |
| 7:00pm | Boys Basketball - Central Catholic vs Butler | |
| 7:00pm | Boys Basketball - Mt. Lebanon vs Upper St. Clair | |
| 7:00pm | Girls Basketball - Chartiers Valley vs Oakland Catholic | |
| 7:00pm | Girls Basketball - Moon vs Indiana | |
| 7:00pm | Girls Basketball - South Fayette vs Latrobe | |
| 7:00pm | Girls Basketball - Trinity vs McKeesport |
# denotes a conference game