Tuesday, April 27, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Baseball - Mt. Lebanon @ Baldwin # | |
| 5:00pm | Baseball - Pine-Richland vs Allderdice # | |
| 5:00pm | Baseball - Central Catholic vs Seneca Valley # | |
| 5:00pm | Baseball - Hempfield vs Canon-McMillan # | |
| 5:00pm | Baseball - Franklin Regional vs Gateway # | |
| 5:00pm | Baseball - Plum vs Penn Hills # | |
| 5:00pm | Baseball - South Fayette @ North Hills # | |
| 5:00pm | Softball - Indiana vs Woodland Hills # | |
| 5:00pm | Softball - Bethel Park vs South Fayette | |
| 5:15pm | Baseball - Chartiers Valley vs Moon # | |
| 5:15pm | Baseball - Albert Gallatin vs Peters Township # | |
| 5:15pm | Softball - Canon-McMillan vs Baldwin # | |
| 5:30pm | Baseball - Shaler @ West Allegheny # | |
| 6:00pm | Baseball - Penn-Trafford @ McKeesport # | |
| 6:00pm | Baseball - Mars @ Woodland Hills # | |
| 8:00pm | Baseball - North Allegheny @ Butler # | |
| 8:00pm | Baseball - Thomas Jefferson @ Trinity # | |
| 8:30pm | Baseball - Latrobe vs Kiski Area # |
# denotes a conference game