Wednesday, April 28, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:30pm | Softball - Trinity @ Moon # | |
| 4:45pm | Softball - Mars @ Oakland Catholic # | |
| 5:00pm | Baseball - Bethel Park @ Connellsville # | |
| 5:00pm | Baseball - Hampton vs Pine-Richland | |
| 5:00pm | Baseball - Fox Chapel vs Shady Side Academy | |
| 5:00pm | Softball - Baldwin vs Canon-McMillan # | |
| 5:00pm | Softball - Seneca Valley vs Pine-Richland # | |
| 5:00pm | Softball - Armstrong @ Kiski Area # | |
| 5:00pm | Softball - Franklin Regional vs Penn Hills # | |
| 5:00pm | Softball - Latrobe vs Albert Gallatin # | |
| 5:00pm | Softball - Penn-Trafford @ Gateway # | |
| 5:00pm | Softball - Thomas Jefferson @ Connellsville # | |
| 5:00pm | Softball - North Hills vs Fox Chapel # | |
| 5:00pm | Softball - Shaler vs Hampton # | |
| 5:00pm | Softball - West Allegheny vs Chartiers Valley # | |
| 5:15pm | Softball - Mt. Lebanon vs Peters Township # | |
| 8:00pm | Baseball - North Allegheny vs Chartiers Valley |
# denotes a conference game