Thursday, May 20, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Softball - Fox Chapel vs Franklin Regional | |
| 5:00pm | Softball - Penn-Trafford vs North Hills | |
| 6:00pm | Softball - Connellsville vs Chartiers Valley | |
| 6:00pm | Softball - Indiana vs Armstrong |
# denotes a conference game