Friday, May 21, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 1:00pm | Baseball - Peters Township vs Latrobe | |
| 1:30pm | Baseball - Bethel Park vs Shaler | |
| 6:00pm | Baseball - Upper St. Clair vs Canon-McMillan | |
| 6:00pm | Baseball - Penn-Trafford vs West Allegheny | |
| 9:00pm | Baseball - Mars vs Franklin Regional |
# denotes a conference game