Friday, September 24, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 8:00pm | Football - Baldwin @ Canon-McMillan # | |
| 8:00pm | Football - Hempfield vs Mt. Lebanon # | |
| 8:00pm | Football - Bethel Park @ Franklin Regional | |
| 8:00pm | Football - Moon @ Fox Chapel | |
| 8:00pm | Football - Peters Township vs Connellsville | |
| 8:00pm | Football - South Fayette vs Latrobe | |
| 8:00pm | Football - Upper St. Clair vs Penn Hills | |
| 8:00pm | Football - West Allegheny @ Kiski Area | |
| 8:00pm | Football - Gateway vs Pine-Richland | |
| 8:00pm | Football - Woodland Hills vs North Hills | |
| 8:30pm | Football - Central Catholic @ North Allegheny # | |
| 9:00pm | Football - Norwin vs Seneca Valley # |
# denotes a conference game