Saturday, September 25, 2021
| Time | Event | Venue/Details |
|---|---|---|
| 12:00pm | Boys Soccer - Connellsville vs Laurel Highlands | |
| 12:00pm | Boys Soccer - Norwin vs Plum | |
| 12:00pm | Girls Soccer - Norwin @ Penn-Trafford # | |
| 1:30pm | Girls Soccer - Allderdice vs Fox Chapel # | |
| 2:30pm | Boys Soccer - Pine-Richland vs Upper St. Clair | |
| 2:30pm | Girls Soccer - Baldwin @ Bethel Park # | |
| 2:30pm | Girls Soccer - Mt. Lebanon vs Upper St. Clair # | |
| 3:00pm | Girls Soccer - Canon-McMillan @ Peters Township # | |
| 3:30pm | Football - Penn-Trafford @ Shaler | |
| 6:30pm | Girls Soccer - North Allegheny vs North Hills # | |
| 7:00pm | Boys Soccer - Baldwin @ Mars | |
| 7:00pm | Girls Soccer - Butler @ Seneca Valley # | |
| 7:30pm | Boys Soccer - Canon-McMillan vs Central Catholic |
# denotes a conference game