Wednesday, April 6, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 5:00pm | Baseball - Connellsville vs Peters Township # | |
| 5:00pm | Softball - Franklin Regional @ Indiana # | |
| 5:00pm | Softball - Kiski Area @ Plum # | |
| 5:00pm | Softball - Albert Gallatin @ Latrobe # | |
| 5:00pm | Softball - Connellsville vs Thomas Jefferson # | |
| 5:00pm | Softball - Fox Chapel @ North Hills # | |
| 5:00pm | Softball - Hampton @ Shaler # | |
| 6:00pm | Softball - Gateway @ Penn-Trafford # | |
| 7:00pm | Softball - Pine-Richland @ Seneca Valley # |
# denotes a conference game