Wednesday, April 20, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 4:00pm | Softball - Norwin @ Shaler | |
| 4:00pm | Softball - Penn Hills @ Woodland Hills # | |
| 4:00pm | Softball - Albert Gallatin @ Southmoreland | |
| 4:00pm | Softball - Connellsville @ Belle Vernon | |
| 4:15pm | Baseball - Fox Chapel vs Hampton # | |
| 4:30pm | Baseball - Central Catholic vs North Allegheny # | |
| 4:45pm | Softball - Armstrong vs Franklin Regional # | |
| 4:45pm | Softball - Moon @ South Fayette # | |
| 5:00pm | Baseball - Butler @ Pine-Richland # | |
| 5:00pm | Baseball - Canon-McMillan vs Norwin # | |
| 5:00pm | Baseball - Gateway @ Latrobe # | |
| 5:00pm | Baseball - Kiski Area @ Penn-Trafford # | |
| 5:00pm | Baseball - Plum @ Woodland Hills # | |
| 5:00pm | Baseball - Moon @ North Hills # | |
| 5:00pm | Baseball - Shaler vs South Fayette # | |
| 5:00pm | Baseball - Connellsville @ Thomas Jefferson # | |
| 5:00pm | Softball - Baldwin @ Thomas Jefferson | |
| 5:00pm | Softball - Butler vs North Allegheny # | |
| 5:00pm | Softball - Indiana vs Kiski Area # | |
| 5:00pm | Softball - North Hills vs Oakland Catholic # | |
| 5:15pm | Baseball - Chartiers Valley @ West Allegheny # | |
| 5:30pm | Softball - Mt. Lebanon vs Peters Township # | |
| 6:00pm | Baseball - Hempfield @ Mt. Lebanon # | |
| 6:15pm | Baseball - Fox Chapel vs Hampton # | |
| 8:00pm | Baseball - Allderdice vs Seneca Valley # | |
| 8:00pm | Baseball - Gateway vs Latrobe # | |
| 8:00pm | Baseball - Bethel Park @ Peters Township # |
# denotes a conference game