Thursday, April 21, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 3:45pm | Baseball - Pine-Richland @ Mars | |
| 3:45pm | Softball - Hampton @ Oakland Catholic # | |
| 4:15pm | Softball - Canon-McMillan vs West Allegheny | |
| 4:30pm | Softball - Mars @ North Hills # | |
| 4:30pm | Softball - Moon vs Upper St. Clair # | |
| 5:00pm | Baseball - Allderdice @ Seneca Valley # | |
| 5:00pm | Baseball - Plum vs Woodland Hills # | |
| 5:00pm | Softball - Franklin Regional vs Plum # | |
| 5:00pm | Softball - Indiana vs Penn Hills # | |
| 5:00pm | Softball - Albert Gallatin @ Penn-Trafford # | |
| 5:00pm | Softball - Latrobe vs Thomas Jefferson # | |
| 7:00pm | Softball - North Allegheny @ Seneca Valley # | |
| 8:00pm | Baseball - Albert Gallatin @ Trinity # | |
| 8:30pm | Baseball - Butler vs Pine-Richland # |
# denotes a conference game