Friday, April 22, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 3:00pm | Softball - Hempfield vs Pine-Richland # | |
| 3:30pm | Softball - Mars @ Moon | |
| 3:45pm | Baseball - Hampton @ Deer Lakes | |
| 3:45pm | Softball - Armstrong vs Highlands | |
| 4:00pm | Baseball - Hempfield @ Plum | |
| 4:00pm | Baseball - Franklin Regional vs McKeesport # | |
| 4:00pm | Baseball - Kiski Area vs Knoch | |
| 4:00pm | Baseball - McKeesport @ Baldwin | |
| 4:00pm | Softball - Bethel Park @ Hempfield | |
| 4:00pm | Softball - Mt. Lebanon @ Chartiers Valley | |
| 4:00pm | Softball - Penn-Trafford vs North Hills | |
| 4:00pm | Softball - Chartiers Valley vs Moon # | |
| 4:00pm | Softball - Armstrong @ Deer Lakes | |
| 4:00pm | Softball - Hampton vs Seneca Valley | |
| 4:15pm | Baseball - Mt. Lebanon vs Moon | |
| 4:15pm | Baseball - Chartiers Valley vs West Allegheny # | |
| 4:15pm | Baseball - Albert Gallatin vs Trinity # | |
| 4:15pm | Softball - West Allegheny @ Beaver | |
| 4:30pm | Baseball - Thomas Jefferson vs South Park | |
| 5:00pm | Baseball - Canon-McMillan @ Norwin # | |
| 5:00pm | Baseball - Upper St. Clair vs Baldwin # | |
| 5:00pm | Baseball - Penn-Trafford @ Connellsville | |
| 5:00pm | Baseball - Armstrong @ Penn Hills # | |
| 5:00pm | Baseball - Penn Hills @ St. Joesph | |
| 5:00pm | Baseball - Moon vs North Hills # | |
| 5:00pm | Baseball - Shaler @ South Fayette # | |
| 5:00pm | Baseball - Bethel Park vs Peters Township # | |
| 5:00pm | Softball - Canon-McMillan @ Pine-Richland | |
| 5:00pm | Softball - Butler @ Hempfield # | |
| 5:00pm | Softball - Indiana @ Plum # | |
| 5:00pm | Softball - Penn Hills @ St. Joseph's | |
| 5:00pm | Softball - Fox Chapel @ Shaler # | |
| 5:00pm | Softball - Trinity @ West Allegheny # | |
| 5:00pm | Softball - Mars vs Shady Side Academy | |
| 5:15pm | Baseball - Hempfield vs Mt. Lebanon # | |
| 5:15pm | Softball - Bethel Park @ Mt. Lebanon # | |
| 5:15pm | Softball - Connellsville @ Greensburg Salem | |
| 6:00pm | Baseball - Central Catholic @ North Allegheny # | |
| 6:00pm | Baseball - Gateway @ Woodland Hills | |
| 7:00pm | Baseball - Upper St. Clair vs Bethel Park | |
| 7:00pm | Baseball - Armstrong @ Highlands | |
| 7:00pm | Baseball - Trinity vs Ringgold | |
| 7:30pm | Baseball - Butler vs Canon-McMillan | |
| 7:30pm | Softball - Baldwin vs Canon-McMillan # | |
| 8:00pm | Baseball - West Allegheny @ Montour | |
| 8:00pm | Softball - South Fayette @ Upper St. Clair # |
# denotes a conference game