Monday, April 25, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 4:45pm | Baseball - Central Catholic vs Seneca Valley # | |
| 4:45pm | Baseball - Armstrong vs Hampton # | |
| 4:45pm | Softball - Armstrong vs Kiski Area # | |
| 4:45pm | Softball - Fox Chapel vs North Hills # | |
| 4:45pm | Softball - Mars @ Oakland Catholic # | |
| 4:45pm | Softball - Mars vs Oakland Catholic # | |
| 4:45pm | Softball - South Fayette vs Brashear | |
| 5:00pm | Baseball - Allderdice @ Pine-Richland # | |
| 5:00pm | Baseball - Canon-McMillan @ Hempfield # | |
| 5:00pm | Baseball - Mt. Lebanon @ Baldwin # | |
| 5:00pm | Baseball - Franklin Regional vs Gateway # | |
| 5:00pm | Baseball - McKeesport vs Penn-Trafford # | |
| 5:00pm | Baseball - Penn Hills @ Plum # | |
| 5:00pm | Baseball - North Hills vs South Fayette # | |
| 5:00pm | Baseball - Shaler @ West Allegheny # | |
| 5:00pm | Baseball - Bethel Park vs Connellsville # | |
| 5:00pm | Baseball - Thomas Jefferson @ Trinity # | |
| 5:00pm | Softball - Baldwin @ Canon-McMillan # | |
| 5:00pm | Softball - Butler vs Hempfield # | |
| 5:00pm | Softball - Pine-Richland vs Seneca Valley # | |
| 5:00pm | Softball - Franklin Regional @ Penn Hills # | |
| 5:00pm | Softball - Plum vs Woodland Hills # | |
| 5:00pm | Softball - Albert Gallatin vs Latrobe # | |
| 5:00pm | Softball - Connellsville @ Thomas Jefferson # | |
| 5:00pm | Softball - Hampton vs Shaler # | |
| 5:00pm | Softball - Chartiers Valley vs West Allegheny # | |
| 5:00pm | Softball - Moon @ Trinity # | |
| 5:00pm | Softball - Upper St. Clair vs Western Beaver # | |
| 5:15pm | Baseball - Chartiers Valley vs Moon # | |
| 5:15pm | Baseball - Albert Gallatin vs Peters Township # | |
| 5:30pm | Softball - Mt. Lebanon @ Peters Township # | |
| 5:45pm | Baseball - Mars vs Woodland Hills # | |
| 6:00pm | Softball - Gateway vs Penn-Trafford # | |
| 7:00pm | Softball - Upper St. Clair @ Western Beaver # | |
| 8:00pm | Baseball - Norwin @ Upper St. Clair # | |
| 8:00pm | Baseball - Latrobe vs Kiski Area # |
# denotes a conference game