Thursday, April 28, 2022
| Time | Event | Venue/Details |
|---|---|---|
| 3:30pm | Baseball - Chartiers Valley @ Allderdice | |
| 3:45pm | Softball - Indiana @ Penn Hills # | |
| 4:00pm | Baseball - Fox Chapel vs Shady Side Academy | |
| 4:00pm | Softball - Hempfield vs North Allegheny # | |
| 4:00pm | Softball - Albert Gallatin vs Northern Garrett (MD) | |
| 4:00pm | Softball - North Hills @ Oakland Catholic # | |
| 4:30pm | Baseball - Allderdice vs Brashear | |
| 4:30pm | Baseball - Butler vs North Allegheny # | |
| 4:30pm | Softball - Bethel Park @ Chartiers-Houston | |
| 4:45pm | Baseball - Armstrong vs Leechburg | |
| 4:45pm | Softball - South Fayette @ Western Beaver # | |
| 5:00pm | Baseball - Seneca Valley vs North Hills | |
| 5:00pm | Baseball - Canon-McMillan vs Trinity | |
| 5:00pm | Baseball - Upper St. Clair @ Moon | |
| 5:00pm | Baseball - Franklin Regional @ McKeesport # | |
| 5:00pm | Baseball - Kiski Area vs Connellsville | |
| 5:00pm | Baseball - Baldwin vs Quaker Valley | |
| 5:00pm | Baseball - Norwin @ Pine-Richland | |
| 5:15pm | Baseball - Albert Gallatin vs University (WV) | |
| 5:15pm | Baseball - Central Catholic @ Hempfield | |
| 5:30pm | Baseball - South Fayette @ Keystone Oaks | |
| 5:30pm | Baseball - West Allegheny vs Blackhawk | |
| 7:30pm | Baseball - Butler vs Franklin Regional | |
| 7:30pm | Softball - Baldwin @ Mt. Lebanon # | |
| 8:00pm | Baseball - Gateway vs Hampton |
# denotes a conference game